Yves Pommier Selected Research

Human immunodeficiency virus 1 p31 integrase protein

7/2018	HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence.
6/2014	4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.
10/2013	Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 gene products.
12/2012	6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.
2/2012	Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.
11/2011	MK-0536 inhibits HIV-1 integrases resistant to raltegravir.
10/2011	Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572).

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Yves Pommier Research Topics

Disease

189	Neoplasms (Cancer) 12/2022 - 01/2002
25	Breast Neoplasms (Breast Cancer) 01/2021 - 01/2003
19	Carcinoma (Carcinomatosis) 01/2018 - 10/2002
19	Poisoning 11/2016 - 07/2002
18	Genomic Instability 01/2022 - 09/2007
16	Leukemia 10/2021 - 08/2002
12	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2022 - 09/2011
12	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2022 - 05/2003
11	Acquired Immunodeficiency Syndrome (AIDS) 07/2018 - 12/2002
10	Hypersensitivity (Allergy) 01/2021 - 10/2006
9	Lung Neoplasms (Lung Cancer) 10/2022 - 08/2002
8	Infections 01/2016 - 01/2009
6	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 12/2007
6	Lymphoma (Lymphomas) 01/2021 - 12/2003
6	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 02/2008
6	Colonic Neoplasms (Colon Cancer) 03/2016 - 03/2002
5	Colorectal Neoplasms (Colorectal Cancer) 12/2022 - 05/2004
5	HIV Infections (HIV Infection) 01/2016 - 03/2005
4	Hypoxia (Hypoxemia) 01/2021 - 02/2004
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 01/2010
4	Ovarian Neoplasms (Ovarian Cancer) 01/2020 - 09/2012
4	Bloom Syndrome 01/2017 - 10/2005
4	Ewing Sarcoma (Sarcoma, Ewing) 09/2015 - 07/2009
3	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2021 - 04/2011
3	Chromosomal Instability (Chromosome Stability) 07/2021 - 02/2016
3	Mitochondrial Diseases (Mitochondrial Disease) 09/2014 - 09/2004
3	Visceral Leishmaniasis (Kala Azar) 10/2012 - 12/2007
3	Sarcoma (Soft Tissue Sarcoma) 02/2011 - 07/2002
2	Bites and Stings (Sting) 10/2022 - 01/2020
2	Urinary Bladder Neoplasms (Bladder Cancer) 02/2022 - 08/2002

Drug/Important Bio-Agent (IBA)

64	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 04/2003
53	Type I DNA Topoisomerases (Topoisomerase I)IBA 12/2022 - 01/2002
52	Pharmaceutical PreparationsIBA 11/2021 - 08/2002
45	CamptothecinIBA 01/2022 - 02/2002
36	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2002
23	Topotecan (Hycamtin)FDA LinkGeneric 01/2022 - 08/2002
17	EnzymesIBA 01/2022 - 05/2003
16	Antineoplastic Agents (Antineoplastics)IBA 10/2022 - 01/2003
16	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2021 - 02/2002
16	Topoisomerase I InhibitorsIBA 01/2020 - 03/2002
15	Biomarkers (Surrogate Marker)IBA 02/2022 - 06/2005
15	Irinotecan (Camptosar)FDA LinkGeneric 01/2021 - 08/2002
14	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2022 - 09/2010
13	NSC 724998IBA 01/2022 - 11/2007
13	tyrosyl-DNA phosphodiesteraseIBA 10/2021 - 12/2006
13	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 09/2002
10	PlatinumIBA 02/2022 - 01/2016
10	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021 - 01/2003
9	PoisonsIBA 10/2022 - 02/2004
9	Phosphotransferases (Kinase)IBA 01/2022 - 10/2002
9	Etoposide (VP 16)FDA LinkGeneric 01/2021 - 11/2003
8	Messenger RNA (mRNA)IBA 01/2021 - 12/2002
8	Topoisomerase InhibitorsIBA 01/2021 - 01/2010
7	Biological ProductsIBA 10/2021 - 11/2004
7	Human immunodeficiency virus 1 p31 integrase proteinIBA 07/2018 - 10/2011
7	IntegrasesIBA 01/2016 - 03/2006
7	TrabectedinIBA 03/2014 - 07/2002
6	talazoparibIBA 01/2021 - 02/2014
6	indimitecanIBA 01/2020 - 12/2012
6	olaparibIBA 01/2020 - 02/2014
6	Histones (Histone)IBA 01/2019 - 06/2005
5	ChromatinIBA 01/2022 - 11/2009
5	Mitochondrial DNA (mtDNA)IBA 01/2022 - 09/2013
5	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2022 - 09/2010
5	Type II DNA Topoisomerases (Topoisomerase II)IBA 01/2021 - 08/2002
5	Transcription Factors (Transcription Factor)IBA 10/2020 - 07/2004
5	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2014 - 12/2008
5	Raltegravir Potassium FDA Link 12/2012 - 01/2009
4	Hormones (Hormone)IBA 01/2022 - 01/2006
4	Gemcitabine FDA Link 01/2021 - 08/2002
4	Histone Deacetylase InhibitorsIBA 01/2021 - 11/2003
4	Paclitaxel (Taxol)FDA LinkGeneric 01/2021 - 01/2003
4	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2021 - 04/2003
4	Mitoxantrone (Novantrone)FDA LinkGeneric 01/2020 - 12/2007
4	Temozolomide (Temodar)FDA LinkGeneric 01/2020 - 09/2015
4	Carboplatin (JM8)FDA LinkGeneric 01/2019 - 01/2016
4	aminoflavoneIBA 01/2017 - 06/2005
4	Small Interfering RNA (siRNA)IBA 03/2014 - 09/2007
3	Drug CombinationsIBA 01/2021 - 06/2004
3	A-Form DNA (A-DNA)IBA 01/2020 - 01/2005
3	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 12/2019 - 12/2004
3	rucaparibIBA 01/2019 - 02/2014
3	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2019 - 09/2007
3	NucleosidesIBA 01/2019 - 01/2014
3	veliparibIBA 01/2018 - 09/2011
3	RNA Helicases (RNA Helicase)IBA 01/2018 - 09/2012
3	LactamsIBA 01/2017 - 05/2007
3	EWS-FLI fusion proteinIBA 09/2015 - 02/2011
3	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2014 - 09/2004
3	Checkpoint Kinase 2IBA 12/2011 - 01/2009
3	DNA-Activated Protein KinaseIBA 12/2009 - 05/2003
3	AphidicolinIBA 09/2007 - 05/2003
3	7-hydroxystaurosporine (UCN 01)IBA 06/2004 - 10/2002
2	AntigensIBA 10/2022 - 01/2022
2	Peptides (Polypeptides)IBA 01/2022 - 01/2009
2	UbiquitinIBA 01/2022 - 08/2008
2	InterferonsIBA 01/2022 - 10/2021

Therapy/Procedure

45	Therapeutics 01/2022 - 08/2002
22	Drug Therapy (Chemotherapy) 02/2022 - 07/2002
2	Immunotherapy 10/2022 - 05/2021